Stem Cell Treatment in IVF/ICSI
represents one of the most promising frontiers in reproductive medicine. At KIC Delfinium, we believe that hope should keep pace with science. For many couples who have not found success with conventional fertility treatments, stem-cell-based therapies offer a carefully designed, research-driven pathway aimed at repairing, restoring, and revitalizing reproductive potential. This innovative approach is particularly being explored to address two major fertility challenges — severely damaged endometrium (uterine lining) and poor ovarian reserve (low or declining egg supply). While still an evolving field, stem cell therapy, when integrated within a structured IVF/ICSI plan, may help open new possibilities for conception that once seemed unattainable.
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Stem Cell Treatment
Stem Cell Treatment at KIC Delfinium focuses on harnessing the regenerative potential of a patient’s own cells (autologous stem cells) to support healing and rejuvenation of reproductive tissues. In fertility care, this technology has two primary applications: first, endometrial regeneration for women with a thin or scarred uterine lining caused by conditions such as genital tuberculosis, Asherman’s syndrome, chronic endometritis, or previous uterine procedures; and second, ovarian function support for women with diminished ovarian reserve, premature ovarian insufficiency, or age-related decline. Through these targeted therapies, KIC Delfinium strives to offer renewed hope and scientific precision to couples on their fertility journey.
What Is Stem Cell Treatment in IVF/ICSI?
Stem Cell Treatment (as applied to fertility) refers to the targeted use of your own regenerative cell fractions—most commonly Platelet-Rich Plasma (PRP) and Bone Marrow-derived cell concentrates—to promote tissue healing and functional support in the endometrium or ovaries. These cell preparations are autologous, meaning they come from your own body, which significantly reduces the risk of rejection or immunologic complications.
How It May Help in Fertility
- Endometrium (uterine lining): The endometrium needs to grow to a receptive thickness and quality for an embryo to implant. In women with severe thinning, scarring, or chronic inflammation, even high-quality embryos may fail to implant. Autologous cell therapies aim to reduce inflammation, promote angiogenesis (new blood vessel formation), and stimulate tissue remodelling, supporting better endometrial receptivity during embryo transfer.
- Ovaries: In women with low ovarian reserve, the objective is to support ovarian microenvironment and, in some reported cases, encourage follicular activity. While outcomes vary and the science is still emerging, carefully selected patients may experience improved response to ovarian stimulation in subsequent IVF/ICSI cycles. This gives better result with PRP.
When Can Stem Cell Treatment Be Considered?
Stem cell therapy is not routinely recommended for every IVF patient. At KIC Delfinium, we reserve it for specific, carefully assessed scenarios, generally after conventional measures have not yielded sufficient improvement.
1) Endometrial Damage and Thin Lining
- Genital Tuberculosis (TB) and Endometrial Damage:
TB is relatively common in our region. Beyond the lungs, TB may involve reproductive organs, causing scarring of the tubes and, in severe cases, injury to the endometrium. IVF can bypass damaged tubes, but a healthy, receptive endometrium is essential for implantation. In select cases of TB-related endometrial compromise (post-treatment and medically inactive), autologous cell therapies may be explored to support endometrial recovery. - Asherman’s Syndrome (Intrauterine Adhesions):
Scarring inside the uterus—a result of infections, D&Cs, or certain surgeries—may reduce the cavity size and impede lining growth. Primary treatment is hysteroscopic adhesiolysis (surgical removal of adhesions). In women with persistent thin lining post-surgery, PRP or bone-marrow-derived cell injections may be considered as an adjunct. - Chronic Endometritis and Recurrent Implantation Failure (RIF):
Some patients have persistent low-grade inflammation of the endometrium or have experienced multiple failed transfers despite euploid (chromosomally normal) embryos. After thorough evaluation and appropriate medical treatment, autologous cell therapy may be considered to enhance receptivity. - Other Causes of Thin Endometrium:
Long-standing hormonal disturbances, prior infections, or uterine instrumentation can lead to thin lining. When standard strategies (oestrogen therapy, vasodilators, intrauterine measures) do not suffice, autologous cell therapy may be discussed.
2) Poor Ovarian Reserve / Premature Ovarian Insufficiency (POI)
- Age-related Decline (commonly after 35):
Ovarian reserve naturally decreases with age. A subset of women show a steeper or earlier decline, reflected in low AMH, low antral follicle counts, and reduced response to stimulation. - Early decline in younger women:
Some women under 35 experience premature ovarian insufficiency or persistent poor response across IVF cycles. After ruling out reversible factors and optimising standard protocols, ovarian-targeted cell therapy may be considered case-by-case.
Where Do the Cells Come From?
Platelet-Rich Plasma (PRP)
• What it is: A concentrated fraction of your own blood rich in platelets and growth factors.
• How we obtain it: A small blood sample is drawn under sterile conditions and processed in a certified protocol to separate the platelet-rich layer.
• How it’s used: Prepared PRP is gently instilled into the uterine cavity (for endometrium) or delivered in controlled protocols to the ovaries (in select cases).
Bone Marrow-Derived Cell Concentrate
• What it is: A cell-rich fraction obtained from a small volume of your bone marrow (commonly from the pelvic bone) under sterile conditions and local anaesthesia.
• How we obtain it: A trained clinician performs a minimally invasive bone marrow aspiration; the sample is processed to concentrate cellular components.
• How it’s used: The concentrate is used according to a pre-defined clinical protocol for endometrial or ovarian applications, always with a focus on safety and comfort.
Both PRP and bone marrow-derived cell therapies at KIC Delfinium are autologous and performed under strict asepsis, quality control, and ethical oversight.
How We Use Stem Cell Therapy Within IVF/ICSI Care
Stem cell therapy is not a standalone treatment; it is integrated into an IVF/ICSI plan where appropriate.
- A) Endometrial-Focused Protocol (Thin/Scarred Lining)
- Baseline Assessment:
Detailed history, ultrasound, hysteroscopy (as indicated), infection screens, and endometrial receptivity assessment. - Optimise Medical Management:
Treat infections, correct hormones, consider vasodilators and adjuvants, and perform adhesiolysis if needed. - Autologous Cell Therapy Session (PRP or Bone Marrow-Derived):
- Performed in a controlled setting.
- Gentle intrauterine instillation or targeted delivery.
- Followed by rest and standard post-procedure care.
- Endometrial Build-Up:
Oestrogen-progesterone protocols as per IVF plan; monitoring of lining thickness and pattern. - Embryo Transfer (Fresh or Frozen):
Planned when the lining appears receptive and overall parameters are favourable. - Post-Transfer Support:
Luteal support, follow-up, and early pregnancy monitoring.
- B) Ovarian-Focused Protocol (Poor Reserve)
- Comprehensive Consultation:
AMH, AFC, prior cycle responses, age, medical history, and realistic goal setting. - Individualised Strategy:
Discuss standard optimisation first (stimulation protocol changes, adjuvants, timing, lab strategy). - Autologous Cell Therapy Session (Selected Patients):
- Performed only after detailed counselling and consent.
- Aimed at supporting the ovarian microenvironment.
- Recovery Interval:
A short interval may be recommended before the next stimulation cycle, based on your plan. - Repeat IVF/ICSI Cycle:
Monitor response closely; decide on trigger and retrieval timing to maximise outcomes. - Embryo Development and Transfer:
Follow lab best practices; transfer in an optimal cycle; provide thorough post-transfer support.
Benefits and Limitations — Balanced, Realistic, Clear
Potential Benefits
- For Endometrium:
- May support lining thickening and receptivity in select thin-lining cases.
- May reduce local inflammation and encourage better vascularity.
- May improve chances of implantation when combined with a well-timed embryo transfer.
- For Ovaries:
- In some patients, may support better response to stimulation.
- Potential to improve overall cycle quality in select scenarios.
- General:
- Autologous (from your own body), which lowers the risk of rejection.
- Can be integrated without disrupting the broader IVF/ICSI plan.
- Provides an option before advancing to donor eggs or surrogacy—especially valuable to couples seeking one more evidence-informed attempt with their own gametes.
Prudent Limitations
- Outcomes are variable; not every patient will see significant improvement.
- It is not a guaranteed solution and should be viewed as an adjunct.
- Multiple factors affect success—age, underlying pathology, ovarian reserve, embryo genetics, uterine health, and overall medical context.
- Some patients may still be better served by egg donation or surrogacy, depending on their goals and clinical profile.
Who Is an Ideal Candidate?
You may be considered for stem cell therapy at KIC Delfinium if:
- You have persistently thin or scarred endometrium despite standard therapy and surgical correction, and you wish to attempt implantation with your own uterus.
- You have recurrent implantation failure after transferring high-grade embryos, and work-up suggests endometrial receptivity issues.
- You have poor ovarian reserve with a strong preference to attempt with your own eggs before moving to donor options—after understanding realistic odds.
- You meet safety criteria (normal infection markers, stable medical status, adequate haemoglobin/platelets, and no contraindications to the required procedures).
Safety, Comfort, and Recovery
- Anaesthesia & Comfort:
PRP preparation requires only a blood draw. Bone marrow aspiration is done under local anaesthesia with experienced clinicians. Intrauterine instillation is typically quick and well tolerated. - Asepsis & Quality Control:
We follow rigorous infection control protocols, single-use disposables where applicable, and certified processing methods. - Recovery:
Most patients can return to routine activities within 24 hours (as advised by your doctor). Mild cramping or spotting may occur and usually settles quickly. - Follow-Up:
You’ll receive a structured follow-up schedule for monitoring, medication adjustments, and cycle planning.
Your Step-by-Step Journey at KIC Delfinium
- Initial Consultation & Case Review
- Detailed medical history, prior reports, and expectations.
- Discussion of standard and advanced options.
- Explanation of stem cell therapy’s role and evidence in your scenario.
- Investigations
- Hormonal evaluation (AMH, FSH, LH, E2, thyroid, vitamin D, etc.).
- Infection screening and imaging as indicated.
- Uterine cavity evaluation (sonography/hysteroscopy) for endometrial cases.
- Counselling & Consent
- Risks, benefits, alternatives (including egg donation/surrogacy).
- Clear documentation and written informed consent.
- Scheduling the Procedure
- Align with your cycle phase (for endometrial therapy) or with planned IVF stimulation (for ovarian therapy).
- Pre-procedure instructions (medications, fasting if needed, logistics).
- Procedure Day
- PRP protocol or bone marrow aspiration performed under asepsis.
- Cell processing in a controlled, validated workflow.
- Targeted delivery (intrauterine/ovarian) as per plan.
- Post-Procedure Care
- Observation and discharge with do’s and don’ts.
- Contact point for any concerns.
- Re-assessment & IVF/ICSI Planning
- Endometrial monitoring or stimulation planning as applicable.
- Decide on fresh vs frozen embryo transfer based on lining and hormonal milieu.
- Embryo Transfer & Luteal Support
- Gentle, ultrasound-guided transfer when the window of implantation is ideal.
- Standard luteal support and early pregnancy monitoring.
Should I Opt for Stem Cell Therapy?
While stem cell therapy holds significant promise, it is still in its early stages of development. Though results have been encouraging, it is important to maintain realistic expectations. Stem cell therapy can be considered when other options like surrogacy or egg donation are either not feasible or acceptable to the couple. Although it may not guarantee miraculous results, it provides a viable option when no other solutions seem available, and it poses no harm to the patient.
At KIC Delfinium Fertility Centre, we are dedicated to exploring every possible avenue to help couples achieve their dream of parenthood. Stem cell therapy may be the solution you’re looking for, especially when faced with challenges like poor ovarian reserve or endometrial damage. Get in touch with us at +91 95997 54455 or email us at info@kicdelfinium.com.
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Frequently Asked Questions (FAQs)
- 1. What is stem cell therapy?
Stem cell therapy is a regenerative treatment that uses the body’s own stem cells to repair or regenerate damaged tissues. It has shown promise in treating various conditions, including fertility issues. Stem cells have the ability to develop into different types of cells, aiding the healing process by replenishing damaged cells, tissues, or organs. In fertility, it can enhance ovarian function, improve egg quality, and potentially increase chances of conception when combined with other treatments like IVF.
- 2. How does stem cell therapy work?
Stem cell therapy works by introducing stem cells into the body to repair damaged tissues. The stem cells are harvested, usually from the patient’s own body (bone marrow or adipose tissue), and then injected into the targeted area. In fertility treatment, stem cells can stimulate the ovaries, rejuvenate eggs, improve sperm function, and enhance overall reproductive health. The stem cells promote regeneration by differentiating into the necessary cell types, boosting the body’s healing ability and fertility.
- 3. Can stem cell therapy cure infertility?
While stem cell therapy cannot fully cure infertility, it can potentially improve fertility by stimulating ovarian function, enhancing egg quality, and improving overall reproductive health. In some cases, stem cell therapy can be used to address underlying issues such as damaged ovaries or poor egg quality, making assisted reproductive technologies like IVF more successful. It’s an innovative treatment that can supplement traditional fertility treatments, but its effectiveness varies depending on individual conditions and the type of infertility.
- 4. How many stem cell therapy sessions are needed?
Typically, stem cell therapy requires one session, although in some cases, a second session may be recommended based on the individual’s response. The therapy is usually integrated into a fertility treatment plan that includes IVF or other assisted reproduction techniques. The number of sessions needed depends on various factors such as the patient’s specific condition, age, and overall health. After the initial session, the doctor will assess the patient’s progress and recommend further treatments if necessary.
- 5. Does stem cell therapy hurt?
Most patients experience only mild soreness or discomfort after stem cell therapy, which is typically managed easily with over-the-counter pain medication. The procedure itself involves harvesting stem cells, which may cause some temporary discomfort in the donor site (such as the abdomen or hip area). The injection of stem cells into the target area, such as the ovaries or uterus, is relatively painless, with any discomfort usually subsiding within a short period. Most people can return to normal activities shortly after the procedure.
- 6. When can I start IVF after stem cell therapy?
You can start IVF treatment immediately after stem cell therapy if the body is ready. In many cases, stem cell therapy is integrated into the IVF treatment cycle. However, your doctor will assess your body’s response to the stem cell procedure and determine the appropriate timing for IVF. Depending on the success of the stem cell treatment in rejuvenating the ovaries or improving egg quality, IVF may proceed in the next cycle or the same cycle, based on individual readiness and progress.
- 7. What are the risks of stem cell therapy?
The risks associated with stem cell therapy are minimal but may include minor side effects like bruising or infection at the injection or harvesting sites. In some cases, there could be an allergic reaction to the stem cells or the substances used in the procedure. However, these risks are generally low, especially when performed by a qualified medical professional. Serious complications are rare, but it’s essential to discuss any potential risks and benefits with your fertility doctor before proceeding.
- 8. Can stem cell therapy help avoid donor eggs or surrogacy?
Stem cell therapy may help some women improve their fertility to the point where they can avoid the need for donor eggs or surrogacy. This is particularly true for women with poor egg quality or ovarian issues. By rejuvenating the ovaries and improving egg quality, stem cells can potentially enhance a woman’s ability to conceive with her own eggs. However, the effectiveness of stem cell therapy varies from patient to patient, and in some cases, donor eggs or surrogacy may still be necessary.
- 9. Are there age limits for stem cell therapy?
There is no strict age limit for stem cell therapy, but the procedure may be more effective in younger women whose ovaries are still relatively healthy. In general, stem cell therapy can improve ovarian function and egg quality, but its success tends to decrease with age. Women over the age of 40 may see limited results due to the natural decline in ovarian reserve. A fertility specialist can assess the suitability of stem cell therapy based on your age, health, and specific fertility issues.
- 10. Can men benefit from stem cell therapy?
Yes, men can benefit from stem cell therapy, particularly those with low sperm count, poor sperm motility, or other male infertility issues. Stem cells can be used to rejuvenate sperm production and improve sperm quality. Various andrology protocols, such as harvesting stem cells from the patient’s own body, are tailored to address male infertility. Stem cell therapy may also enhance sperm morphology and motility, increasing the chances of successful fertilization when used in combination with IVF or ICSI.
- 11. What are the costs of stem cell therapy?
The cost of stem cell therapy can vary depending on the clinic, location, and the type of treatment required. On average, stem cell therapy for fertility treatment may range from a few thousand to several thousand dollars per session. The total cost also depends on the number of sessions required and whether additional procedures, such as IVF or egg freezing, are part of the treatment plan. Clinics usually offer transparent pricing and estimates based on the patient’s individual treatment plan.
- 12. Will stem cell therapy delay my IVF journey?
Stem cell therapy is designed to complement IVF treatment, and in most cases, it will not delay your IVF journey. The therapy is often integrated into the IVF process to enhance egg quality and ovarian function before starting IVF. Depending on the patient’s health and response to the treatment, stem cell therapy can be completed within one IVF cycle or even before. The fertility specialist will monitor the patient’s progress and advise on the best course of action to ensure timely IVF treatment.
- 13. Do I need bed rest after stem cell therapy?
No, bed rest is not required after stem cell therapy. Most patients can resume light activities and normal daily routines immediately after the procedure. However, strenuous physical activities and heavy lifting should be avoided for a short period of time to ensure proper healing and reduce the risk of complications. It’s important to follow the specific post-treatment guidelines provided by the fertility specialist to promote recovery and enhance the effectiveness of the stem cell therapy.
- 14. How soon can I expect results from stem cell therapy?
The results of stem cell therapy can vary depending on the individual’s fertility condition and the response to the treatment. Some patients may notice improvements in ovarian function, egg quality, or sperm health within a few months, while others may take longer. It’s important to follow up with the fertility clinic for regular monitoring and assessments after treatment. Typically, the results of stem cell therapy are evaluated before IVF treatment, and if necessary, additional sessions can be considered.
- 15. Is stem cell therapy covered by insurance?
In most cases, stem cell therapy is not covered by standard health insurance policies, as it is considered an experimental or elective treatment. However, some fertility clinics may offer financing options or payment plans to make the therapy more affordable. It’s recommended to check with the clinic beforehand regarding payment options and whether any part of the therapy may be covered by insurance. Be sure to discuss the costs upfront to avoid any surprises later.
- 16. Can stem cell therapy improve male fertility?
Yes, stem cell therapy can improve male fertility, particularly in men with low sperm count, poor sperm motility, or other sperm-related issues. Stem cells are used to stimulate the production of healthy sperm and can potentially improve sperm quality and quantity. This therapy can be combined with other assisted reproductive technologies such as IVF or ICSI to increase the chances of successful fertilization. However, the success of stem cell therapy depends on the individual’s health and the severity of the fertility issues.
- 17. Can stem cell therapy be used to treat egg freezing or preservation?
Yes, stem cell therapy may improve the quality of eggs before freezing, particularly for women with reduced ovarian reserve. By rejuvenating the ovaries and encouraging the growth of healthy eggs, stem cells can increase the chances of successful egg freezing and future use. This is particularly helpful for women who are considering egg freezing for fertility preservation but have concerns about egg quality or quantity due to age or medical conditions. The fertility specialist will assess the suitability of stem cell therapy in this context.
- 18. Is stem cell therapy safe for pregnancy?
Stem cell therapy is generally considered safe for women who are trying to conceive. The procedure involves harvesting stem cells and injecting them into the ovaries or reproductive system, which does not interfere with natural pregnancy processes. However, stem cell therapy is not typically performed during pregnancy, as its effects on an already established pregnancy are not well understood. Women undergoing stem cell therapy should consult with their fertility specialist before pregnancy to ensure safety and suitability for their condition.
- 19. How is stem cell therapy different from traditional fertility treatments?
Stem cell therapy is a more advanced, regenerative treatment that aims to rejuvenate ovarian function and improve egg quality, whereas traditional fertility treatments like IVF and IUI focus on fertilization and embryo transfer. Stem cells work by stimulating the body’s natural regenerative abilities, which can improve the chances of success in other fertility treatments. Traditional treatments address the immediate reproductive issue, while stem cell therapy aims to address the underlying fertility problem, particularly for those with diminished ovarian reserve or poor egg quality.
- 20. Is stem cell therapy suitable for women with PCOS?
Yes, stem cell therapy may be beneficial for women with Polycystic Ovary Syndrome (PCOS), as it can help regulate hormone levels, improve ovarian function, and increase egg quality. For women with PCOS, the therapy may help restore normal ovulation, which can improve the chances of conception. Stem cells can also address the underlying causes of infertility associated with PCOS, such as ovarian cysts and irregular menstrual cycles. However, the success of the therapy will depend on the severity of the condition and the individual’s response.
Contact Us
KIC Delfinium Fertility Centre
F-21, South Ex, Part 1, New Delhi 110049
+91 9599754455
Info@kicdelfinium.com
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