Endometrium and Infertility: Understanding the Connection and Effective Treatment Solutions | KIC Delfinium

13 November 20250Fertility

Endometrium and Infertility: Understanding the Connection and Effective Treatment Solutions | KIC Delfinium

13 November 2025 0
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The endometrium, the soft and vascular inner lining of the uterus, plays a vital role in achieving and maintaining pregnancy. It serves as the nurturing foundation where the embryo implants and begins its early development. Any irregularity in the growth, structure, or receptivity of the endometrium can lead to infertility or recurrent pregnancy loss.
At KIC Delfinium, under the expert care of Dr. Nalini Gupta, women receive advanced diagnosis and personalized fertility treatments designed to address endometrial-related infertility. The center provides specialized thin endometrium treatment in Delhi, focusing on improving uterine blood flow, hormonal balance, and endometrial regeneration through innovative therapies such as PRP treatment and hormonal support to optimize fertility outcomes.

Endometrium and Infertility

The endometrium naturally changes throughout a woman’s menstrual cycle. Under the influence of estrogen, it thickens in preparation for embryo implantation, and progesterone helps mature it during the luteal phase.
If pregnancy occurs, the lining supports the embryo and aids in placental development. If not, it sheds during menstruation.
An ideal endometrial thickness (around 7.5–8 mm or more) is essential for successful implantation, whether during natural conception or assisted reproductive techniques such as IVF. Let’s understand more about the connection between the endometrium and infertility.

Common Endometrial Causes of Infertility

1. Thin Endometrium

A thin endometrial lining (less than 7 mm) can make it difficult for an embryo to implant or survive, leading to infertility or early miscarriage.
Common causes include:
• Asherman’s Syndrome (uterine adhesions and scarring)
• Chronic infections such as endometritis or tuberculosis
• Repeated uterine procedures like D&C or curettage
• Hormonal imbalances or age-related estrogen decline
A thin endometrium has poor blood flow and limited cellular activity, reducing the chances of implantation.
At KIC Delfinium, Dr. Nalini Gupta offers customized hormonal therapies and regenerative techniques like PRP (Platelet-Rich Plasma) therapy to stimulate endometrial growth and improve conception chances.

2. Thick or Hypertrophic Endometrium

An overly thick endometrium (more than 15 mm) can also create difficulties in conception.
Possible causes include:
• Excess estrogen levels due to hormonal imbalance
• Endometrial polyps or submucosal fibroids
These conditions can interfere with normal embryo implantation and lead to irregular bleeding.
At KIC Delfinium, accurate diagnosis through ultrasound and hysteroscopy ensures the right treatment approach for better fertility outcomes.

3. Endometrial Adhesions and Infections

Uterine infections or scar tissue (adhesions) can harm the endometrial surface, reducing its receptivity.
Diagnosis:
Hysteroscopy and endometrial biopsy help identify infections and adhesions.
Treatment:
At KIC Delfinium, hysteroscopic surgery is used to remove adhesions, followed by targeted antibiotic therapy to clear infections. This approach restores the uterine cavity and enhances the chances of successful embryo implantation.

4. Fluid Accumulation in the Endometrium

In some women, fluid buildup inside the uterus, often caused by hydrosalpinx (fluid-filled fallopian tubes), can reduce implantation rates and IVF success.
In such cases, Dr. Nalini Gupta may recommend laparoscopic procedures to block or remove the affected tubes, creating a healthier uterine environment for embryo transfer.

Advanced Treatments to Improve Endometrial Fertility

At KIC Delfinium, a wide range of evidence-based fertility treatments are offered to enhance endometrial health and improve conception chances:
1. Hysteroscopic Surgery:
Removal of fibroids, polyps, and adhesions to improve the uterine environment.
2. Intrauterine Device (IUD):
Used temporarily after surgery to prevent the recurrence of adhesions.
3. Targeted Antibiotic Therapy:
Administered to treat persistent uterine infections confirmed through biopsy.
4. Platelet-Rich Plasma (PRP) Therapy:
A cutting-edge regenerative treatment to enhance endometrial growth in women with thin linings.
5. Hormonal Therapy:
Personalized estrogen and progesterone support to build a receptive endometrium before embryo transfer.
6. Surgical Management of Hydrosalpinx:
Removal or clipping of the affected fallopian tubes to eliminate fluid accumulation.
7. Assisted Reproductive Technologies (ART):
When medical or surgical treatments alone are insufficient, IVF or ICSI is recommended to help couples achieve pregnancy.

Frequently Asked Questions (FAQs)

Q1: What is the function of the endometrium in fertility?
A: The endometrium supports embryo implantation and early growth, making its thickness and health vital for pregnancy.
Q2: How does a thin endometrium affect fertility?
A: A thin lining reduces implantation potential and may lead to infertility or recurrent pregnancy loss.
Q3: Can a thick endometrium cause infertility?
A: Yes. Excessive thickening caused by hormonal imbalance or fibroids can interfere with embryo implantation.
Q4: What causes endometrial adhesions?
A: Adhesions may form after uterine surgery, infection, or trauma, leading to reduced endometrial receptivity.
Q5: Are there effective treatments for thin endometrium?
A: Yes. Hysteroscopic surgery, PRP therapy, hormonal medication, and IVF are effective approaches to improve endometrial health and fertility.
Q6: How is fluid in the uterus treated?
A: When fluid results from hydrosalpinx, laparoscopic removal or tube clipping is performed to enhance implantation success.

Conclusion

The health and receptivity of the endometrium are essential for every woman’s fertility journey. Whether the issue is a thin lining, thickened endometrium, or uterine adhesions, timely medical care and modern treatments can make a life-changing difference.
At KIC Delfinium, under the experienced guidance of Dr. Nalini Gupta, women receive compassionate, evidence-based, and advanced fertility care to achieve their dream of motherhood.


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As per ICMR and PCPNDT Guidelines No Pre Natal Sex Determination is done at KIC Delfinium Fertility Centre. As per ICMR and PCPNDT Guidelines Genetic Counselling can only be done in person.

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